Philosophy of Technology in the Americas in the Last Twenty-Five Years

This article summarizes and analyzes some of the most important contributions to the voluminous literature in philosophy of technology that has been produced during the past twenty-five years in North, Central, and South America. (Major focus is on North America.) The survey emphasizes the variety of standards the authors have attempted to measure up to, and ends with a plea that, whatever the standard invoked, an overarching standard ought to be to contribute to the solution of real-world problems of technological society

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations.

"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population. Quantile-specific offspring-parent regression slopes (βOP) were estimated by quantile regression for 6227 offspring-parent pairs. Quantile-specific heritability (h2), estimated by 2βOP/(1 + rspouse), decreased 0.0047 ± 0.0007 (P = 2.9 × 10-14) for each one-percent decrement in fasting triglyceride concentrations, i.e., h2 ± SE were: 0.428 ± 0.059, 0.230 ± 0.030, 0.111 ± 0.015, 0.050 ± 0.016, and 0.033 ± 0.010 at the 90th, 75th, 50th, 25th, and 10th percentiles of the triglyceride distribution, respectively. Consistent with quantile-dependent expressivity, 11 drug studies report smaller genotype differences at lower (post-treatment) than higher (pre-treatment) triglyceride concentrations. This meant genotype-specific triglyceride changes could not move in parallel when triglycerides were decreased pharmacologically, so that subtracting pre-treatment from post-treatment triglyceride levels necessarily created a greater triglyceride decrease for the genotype with a higher pre-treatment value (purported precision-medicine genetic markers). In addition, sixty-five purported gene-environment interactions were found to be potentially attributable to triglyceride's quantile-dependent expressivity, including gene-adiposity (APOA5, APOB, APOE, GCKR, IRS-1, LPL, MTHFR, PCSK9, PNPLA3, PPARγ2), gene-exercise (APOA1, APOA2, LPL), gene-diet (APOA5, APOE, INSIG2, LPL, MYB, NXPH1, PER2, TNFA), gene-alcohol (ALDH2, APOA5, APOC3, CETP, LPL), gene-smoking (APOC3, CYBA, LPL, USF1), gene-pregnancy (LPL), and gene-insulin resistance interactions (APOE, LPL)

Religion and Ecology: Developing a Planetary Ethic by Whitney A. Bauman

Review of Whitney A. Bauman\u27s Religion and Ecology: Developing a Planetary Ethic

The School Finance Redesign Project: A Synthesis of Project Work to Date

Highlights the School Finance Redesign Project's early findings on the funding needed for all students to meet academic standards, promising ideas for focusing funding on promoting learning and rewarding educators, and the current system's constraints

Ecocriticism on the Edge: The Anthropocene as a Threshold Concept by Timothy Clark

Review of Timothy Clark\u27s Ecocriticism on the Edge: The Anthropocene as a Threshold Concept